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Thiamine Supplementation Improved Lipid Levels


A study published in January 2014 reports that thiamine supplementation improves lipid levels and markers of kidney function in individuals with type 2 diabetes. Currently, 8.3 percent of Americans have diabetes. Diabetes is the leading cause of kidney failure, accounting for 44 percent of new cases. Additionally, adult diabetics have heart disease death rates about two-to-four times higher than adults without diabetes.

The subjects included 60 individuals with type 2 diabetes and 26 individuals without diabetes matched for age and body mass index. The subjects received 100 mg of thiamine (B1) daily for six months. The researchers evaluated metabolic profiles, serum thiamine and body measures routinely.

The investigators found that thiamine supplementation resulted in significantly decreased total cholesterol levels after three months of supplementation and decreased high-density lipoprotein (HDL) cholesterol after six months of supplementation. Additionally, the researchers showed that serum creatinine—a marker of kidney function—significantly improved with thiamine supplementation.

Blood and urine levels of thiamine and its derivatives also improved. Among the subjects with type 2 diabetes, thiamine supplementation improved mean low-density lipoprotein (LDL) cholesterol, total cholesterol, serum and urine thiamine and thiamine derivatives and serum creatinine.

The researchers concluded, “Thiamine supplementation is a promising adjuvant therapy for patients with type 2 diabetes mellitus. Longer clinical trials are needed to determine its protective effect in type 2 diabetes mellitus complications.”

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