中文English

Home >> Facts&Visions >> Facts >> Mixed vitamin E may support blood vessel health

Mixed vitamin E may support blood vessel health

11.14.2012

Mixed vitamin E may support blood vessel health in healthy adults

Short-term supplementation with vitamin E may support the function of cells lining blood cells from potential damage during the increase in blood sugar levels after eating, says a new study.

Five days of supplementation with a gamma-tocopherol-rich mixture of tocopherols maintained vascular endothelia function – the function of the cells lining blood vessels, according to findings published in the Journal of Nutritional Biochemistry .

The vitamin E supplement was also associated with supporting blood flow in the arteries and a reduction in increaseof malondialdehyde (MDA - a reactive carbonyl compound and a well-established marker of oxidative stress).

“This study demonstrates that short-term gamma-tocopherol-rich mixture of tocopherols supplementation in health men maintains vascular endothelial function that is otherwise impaired by postprandial hyperglycemia likely by decreasing lipid peroxidation without affecting inflammatory responses,”

There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main source found in supplements and in the European diet, while gamma-tocopherol is the most common form in the American diet.

Study details

the researchers recruited 15 health men with an average age of 22 to participate in their randomized, crossover study. The men were randomly assigned to receive the vitamin E supplement or no supplement for five days prior to fasting and then receiving 75 grams of glucose.

The vitamin E supplement provided 500 milligrams of gamma-tocopherol, 60 mg of alpha-tocopherol, 170 mg of delta-tocopherol, and 9 mg of beta-tocopherol.

Results showed that the glucose test produced significant increases in MDA levels, and decreases of 30-44% in blood flow, as measured by brachial artery flow-mediated dilation (FMD). However, vitamin E supplementation prevented such changes.

The researchers also report for the first time that vascular endothelial function was maintained in the men after consuming the vitamin E supplement.

No changes in inflammatory markers were observed, indicating that the potential benefits of the vitamin E mix were not related to anti-inflammatory activity.

“Further study is needed to more fully define the specific mechanisms by which gamma-tocopherol-rich mixture of tocopherols maintains vascular endothelial function that is otherwise impaired by postprandial hyperglycemia. Moreover, long-term studies investigating the cardioprotective effects of gamma-tocopherol-rich mixture of tocopherols are also needed to examine its potential benefit as a strategy to mitigate CVD risk.”

|   About Us   |   Products   |   Service   |   Info&Events   |   Facts&Visions   |   Contact   |   

2005-2017 www.kangcare.com. All right reserved.    Jiangsu ICP NO.07503365-1